A: Yes — once mounted or installed, the game runs without the disc if you apply the No-CD Crack (only for legally owned copies). The crack is separate from piracy; it’s a fair use backup solution.
It looks like you're asking for an article based on the keyword — which appears to be a combination of terms related to Grand Theft Auto: San Andreas for PC, possibly referencing an ISO file (a disc image format) or a mobile/emulator-related version.
A: An ISO preserves the original disc layout and may include extras (videos, audio tracks). An EXE installer is a compressed setup file. Both achieve the same result after installation.